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1. Determine how the organization's NPI will be defined. 2. Identify all existing provider identifiers. 3. Identify which, if any, employed providers will need enumeration-organizational, individual, subparts. Subparts are separate physical locations, often separately certified or licensed. Examples: A hospital having two out patient departments, a Surgi-center, a psychiatric unit and a laboratory; or a DME with 20 different service locations. 4. Identify how legacy identifiers are currentlya. Obtained b. Maintained c. Disseminated d. Validated 5. Identify how NPI will bea. Obtained b. Maintained c. Disseminated d. Validated 6. Identify and update affected policies and procedures 7. Determine how legacy identifiers will be managed during the transition? 8. Determine how you will bill for services in multiple locations tax IDs 9. Will someone else enumerate individuals? 10. Have you requested your NPI? If not, you can review NPPES NPI Application instructions at- s: nppes.cms.hhs.gov 11. Determine your application process EFI Electronic File Interchange ; Individually Subpart 12. Apply for NPI s ; in one of the following ways Web based application: s: nppes.cms.hhs.gov Paper application submitted to the Enumerator. The Enumerator's mailing address can be obtained at: s: nppes.cms.hhs.gov. To obtain a paper application call 1.800.465.3203 or TYY 1.800.692.2326 Develop test plans and schedule testing with trading partners Clearing House s ; Payers Third party contractors 1. Determine when payers will begin accepting requiring NPI 2. Determine preparation to use the new paper claim forms. At the end of the transition period only the new forms will be acceptable 1500 HICF Health Insurance Claim form ; Transition Period: October 1, 2006- February 1, 2007 UB04 Form-Transition Period: March 1, 2007- May 22, 2007.
EXHIBIT INDEX Exhibit No. 2.1 3.1 3.2 Description of Document Agreement and Plan of Merger among the Registrant formerly EasyWeb, Inc. ; , ZIO Acquisition Corp. and ZIOPHARM, Inc., dated August 3, 2005 incorporated by reference to Exhibit 10.1 to the Registrant's Form 8-K filed August 9, 2005 ; . Certificate of Incorporation of the Registrant formerly EasyWeb. Inc. ; , as filed with the Delaware Secretary of State on May 16, 2005 incorporated by reference to Exhibit 3.1 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Certificate of Merger dated September 13, 2005, relating to the merger of ZIO Acquisition Corp. with and into ZIOPHARM, Inc. incorporated by reference to Exhibit 3.1 to the Registrant's Form 8-K filed September 19, 2005 ; . Certificate of Ownership of the Registrant formerly EasyWeb, Inc. ; dated as of September 14, 2005, relating the merger of ZIOPHARM, Inc. with and into the Registrant and changing the Registrant's corporate name from EasyWeb, Inc. to ZIOPHARM Oncology, Inc. incorporated by reference to Exhibit 3.2 to the Registrant's Form 8-K filed September 19, 2005 ; . Bylaws, as amended to date incorporated by reference to Exhibit 3.3 to the Registrant's Form 8-K filed September 19, 2005 ; . Specimen common stock certificate. incorporated by reference to Exhibit 4.1 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Form of Warrant issued to placement agents in connection with ZIOPHARM, Inc. 2005 private placement incorporated by reference to Exhibit 4.2 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Schedule identifying holders of Warrants in the form filed as Exhibit 4.2 to this Report incorporated by reference to Exhibit 4.3 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Warrant for the Purchase of Shares of Common Stock dated December 23, 2004. incorporated by reference to Exhibit 4.4 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Option for the Purchase of Common Stock dated October 15, 2004 and issued to DEKK-Tec, Inc. Form of Option for the Purchase of Shares of Common Stock dated October 15, 2004 and issued to The University of Texas M.D. Anderson Cancer Center. Schedule identifying material terms of Options for the Purchase of Shares of Common Stock in the form filed as Exhibit 4.6 to this Report. 2003 Stock Incentive Plan incorporated by reference to Exhibit 10.1 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Employment Agreement dated January 8, 2004, between the Registrant and Dr. Jonathan Lewis incorporated by reference to Exhibit 10.2 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Employment Agreement dated January 15, 2004, between the Registrant and Dr. Robert Peter Gale incorporated by reference to Exhibit 10.3 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Employment Agreement dated July 21, 2004, between the Registrant and Richard Bagley incorporated by reference to Exhibit 10.4 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Patent and Technology License Agreement dated August 24, 2004, among ZIOPHARM, Inc. predecessor to the Registrant ; , the Board of Regents of the University of Texas System on behalf of the University of Texas M.D. Anderson Cancer Center and the Texas A&M University System incorporated by reference to Exhibit 10.5 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . + License Agreement dated October 15, 2004, between ZIOPHARM, Inc. predecessor to the Registrant ; and DEKK-Tec, Inc. incorporated by reference to Exhibit 10.6 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . + Form of subscription agreement between the ZIOPHARM, Inc. and the investors in ZIOPHARM, Inc.'s private placement incorporated by reference to Exhibit 10.7 to the Registrant's Registration Statement on Form SB-2 SEC File No. 333-129020 ; filed October 14, 2005 ; . Form of Incentive Stock Option Agreement granted under 2003 Stock Option Plan Form of Employee Non-Qualified Stock Option Agreement granted under 2003 Stock Option Plan 33. Article 22 states " 1 ; Human rights nongovernmental organizations can appear in court as parties in cases involving discriminations pertaining to their field of activity and that prejudice a community or a group of persons. 2 ; The organizations provided in the above paragraph can also appear in court as parties in cases involving discrimination that prejudice a natural entity, if the latter delegates the organization to that effect." Law No. 48 2002 on approving the Ordinance 137 2000 on preventing and sanctioning all forms of discrimination, Official Gazette 69 from January 31, 2002, arts. 1 2 ; e ; 11, 1 2 ; 3 ; v ; , 15, 22 1. The test for Salmonella spp. in Radix Glycyrrhizae products should be negative. The maximum acceptable limits of other microorganisms are as follows 18, 19, 20 ; . For preparation of decoction: aerobic bacteria--not more than 107 g; fungi--not more than 105 g; Escherichia coli--not more than 102 g. Preparations for internal use: aerobic bacteria--not more than 105 g or ml; fungi--not more than 104 g or ml; enterobacteria and certain Gram-negative bacteria--not more than 103 g or ml; Escherichia coli--0 g or ml. Dopamine to cause adverse cardiac effects 35 ; Vargo et al. 36 ; studied eight patients with congestive cardiac failure. An infusion of low-dose dopamine produced only a modest natriuresis and failed to enhance the response to furosemide. Moreover, two subjects had adverse cardiac events. This study does not suggest a role for dopamine to enhance furosemide natriuresis. Novel adenosine type 1 receptor A1 ; antagonists inhibit NaCl reabsorption in the proximal tubule, block the TGF, and increase the GFR without effects on the heart 37 ; . Brater et al. 38 ; studied the response of patients with heart failure and mild renal insufficiency to an A1 antagonist. The drug increased the GFR and caused a natriuresis without loss of potassium. Its effects were additive with furosemide; therefore, this therapy has the potential to treat diuretic resistance in a novel manner. Correction of metabolic acidosis and prevention of uremic accumulation of organic anions and urate by dietary protein restriction are rational methods to enhance proximal tubule diuretic secretion, but have not been subjected to clinical trial. Several drugs compete with loop diuretics for proximal secretion and thereby may diminish diuretic efficacy 20 ; Table 2 ; . Bumetanide and torsemide are metabolized by the liver, whereas furosemide is metabolized by the kidneys. Therefore, when needed for prolonged, high-dosage therapy in CRI, bumetanide or torsemide may be preferable because they do not accumulate. Trosemide has an aldosterone antagonist action in animal models 39 ; that could perhaps contribute to hyperkalemia in patients with CRI. However, this has not been apparent in clinical studies 11 ; . A strategy in diuretic resistant patients with mild CRI is to combine a loop with a distal acting diuretic, such as a thiazide, to prevent reabsorption of NaCl and fluid in adapted downstream segments 40 ; . In instructive study, Wollam et al. 8 ; studied the effects of increasing the dose of furosemide or adding escalating doses of a thiazide diuretic to a group of mildly azotemic hypertensive subjects. Doubling the furosemide dosage had little effect on their body weight, BP, or SCr, thereby demonstrating loop diuretic resistance. In contrast, the addition of 70 mg daily of hydrochlorothiazide normalized the BP and resulted in a substantial loss in body weight. However, the cost of this beneficial effect on BP and body fluid accumulation was a sharp increase in the SCr and a reduction in the serum potassium concentration SK ; . Therefore, combined therapy with a loop and a thiazide di. After completing the 2006 drilling season, and with over 55, 000 m drilled since 2003, the latest global resource estimate released in December 2006 ; now amounts to 2.8 Moz of gold, with 1.7 Moz in the Indicated category at an average grade of 0.9 g t, and the remainder in Inferred resources. The new estimate has substantially upgraded the Jinxi resource adding 680 koz in Indicated resources and over 515 koz in Inferred. In addition it has included a new resource of 161 koz gold in situ at Lion. The Balake prospect discovered in 2006 ; is now included in the Jinxi deposit. The breakdown of resources, using a 0.5 g t cut-off, is shown in the table below. Category and glucophage. Torsemide price
Relationship between anabolic agents and malignant disease in athletes. The link to malignant hepatomas is tenuous. There are only single case reports of a Wilms tumour in an adult, adenocarcinoma of the colon and prostate malignancy in athletes taking anabolic steroids. However, the link between the vascular tumour peliosis hepatitis and anabolic steroids has been well established.
Drug Name thioridazine hcl TABLET thiothixene CAPSULE THYROLAR-1 2 TABLET THYROLAR-1 4 TABLET THYROLAR-1 TABLET THYROLAR-2 TABLET THYROLAR-3 TABLET TICE BCG FOR SUSPENSION ticlopidine hcl TABLET TIKOSYN CAPSULE TILADE AEROSOL SOLN TIMENTIN SOLUTION TIMENTIN FOR SOLUTION timolol maleate ophthalmic Gel forming GEL FORM SOLN TIMOLOL MALEATE TABLET timolol maleate SOLUTION TINDAMAX TABLET tizanidine hcl TABLET TOBRADEX OINTMENT TOBRADEX SUSPENSION tobramycin sulfate SOLUTION tobramycin sulfate FOR SOLUTION tolazamide TABLET TOLBUTAMIDE TABLET TOPAMAX SPRINKLE CAP SPRINKLE TOPAMAX TABLET TOPROL XL TAB ER 24HR torsemide TABLET tpn electrolytes ftv SOLUTION TRACLEER TABLET tramadol hcl TABLET tramadol hydrochloride acetaminophen TABLET tranylcypromine sulfate TABLET TRAVASOL 5.5% DEXTROSE 10% SOLUTION TRAVASOL 5.5% DEXTROSE 20% SOLUTION TRAVASOL 8.5% DEXTROSE 10% SOLUTION TRAVASOL 8.5% DEXTROSE 20% SOLUTION TRAVASOL 8.5% DEXTROSE 50% SOLUTION travasol 8.5% electrolytes SOLUTION TRAVASOL SOLUTION TRAVATAN Z SOLUTION TRAVATAN SOLUTION and starlix. Torsemide diureticNotwithstanding the provisions regarding termination of coverage described in Ending Coverage, you may be entitled to extended or continued coverage as follows: COBRA continuation coverage Continued coverage shall be provided as required under the Consolidated Omnibus Budget Reconciliation Act of 1985 COBRA ; , as amended as well as the Public Health Service Act PHSA ; , as amended ; . The employer shall, within the parameters of federal law, establish uniform policies pursuant to which such continuation coverage will be provided. See General COBRA Information in this section. USERRA continuation coverage Continued coverage shall be provided as required under the Uniformed Services Employment and Reemployment Rights Act of 1994 "USERRA" ; , as amended. The employer shall, within the parameters of federal law, establish uniform policies pursuant to which such continuation coverage will be provided. See General USERRA Information in this section. 44. Verdrengh M, Jonsson IM, Holmdahl R, and Tarkowski A. Genistein as an anti-inflammatory agent. Inflamm Res 52: 341346, 2003. Walker HA, Dean TS, Sanders TA, Jackson G, Ritter JM, and Chowienczyk PJ. The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17 -estradiol. Circulation 103: 258 262, Wang N, Verna L, Chen NG, Chen J, Li H, Forman BM, and Stemerman MB. Constitutive activation of peroxisome proliferatoractivated receptor- suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells. J Biol Chem 277: 34176 34181, Wiseman H, O'Reilly JD, Adlercreutz H, Mallet AI, Bowey EA, Rowland IR, and Sanders TA. Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. J Clin Nutr 72: 395 400, Wu J, Wang X, Chiba H, Higuchi M, Nakatani T, Ezaki O, Cui H, Yamada K, and Ishimi Y. Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism 53: 942948, 2004. Yamakoshi J, Piskula MK, Izumi T, Tobe K, Saito M, Kataoka S, Obata A, and Kikuchi M. Isoflavone aglycone-rich extract without soy protein attenuates atherosclerosis development in cholesterol-fed rabbits. J Nutr 130: 18871893, 2000. Zhang Y, Hendrich S, and Murphy PA. Glucuronides are the main isoflavone metabolites in women. J Nutr 133: 399 404 and lamisil. Bumex 2mg - 30 tabs Zaroxolyn 10mg Demadex 10mg - 30 Chlorthalidone 50mg - 30 tabs Dyazide 37.5-25mg - 30 caps tabs Zaroxolyn 5mg Diamox Sequels 500mg - 1 Demadex 20mg - 30 tabs cap Edecrin 25mg - 30 tabs Hydrochlorothiazide 12.5mg - Dyrenium 50mg - 30 Furosemide 20mg - 30 tabs 30 caps caps Furosemide 10mg ml Furosemide 40mg - 30 tabs Lasix 40mg - 30 tabs soln - 8 oz Furosemide 80mg - 30 tabs Lasix 80mg - 30 tabs Lozol 1.25mg - 30 tabs Maxzide 75-50mg - 30 Hydrochlorothiazide 25mg - 30 tabs tabs Maxzide-25mg - 30 tabs Methazolamide 50mg Hydrochlorothiazide 50mg - 30 Methyclothiazide 5mg - 30 60 tabs tabs tabs Metolazone 2.5mg - 30 Indapamide 1.25mg - 30 tabs Microzide 12.5mg - 30 caps tabs Metolazone 5mg - 30 Indapamide 2.5mg - 30 tabs Moduretic 5-50mg - 30 tabs tabs Naturetin-5 5mg - 30 Spironolactone 25mg - 30 tabs Lasix 20mg - 30 tabs tabs Triamterene w Hctz 37.5-25mg Spironolactone w Hctz 25Spironolactone 100mg - 30 tabs 25mg - 30 tabs 30 tabs Prices are subject to change Triamterene w Hctz 75-50mg Spironolactone 50mg 30 tabs Torsemlde 10mg - 30 tabs 30 tabs. Correspondence: Cecilie Johannessen Landmark, Ph.D., Associate Professor, Department of Pharmacy, Faculty of Health Sciences, Oslo University College, Pilestredet 50, N-0167 Oslo, Norway. Tel: + 47 22 Fax: + 47 22 Email: cecilie.landmark hf.hio.no. The undertakings set out in this letter are given by Hoechst AG and Rhne-Poulenc S.A. to the Commission of the European Communities pursuant to Council Regulation EEC ; No. 4064 89 of 21 December 1989 on the control of concentrations between undertakings as amended ; in the context of the proposed merger between Hoechst AG "Hoechst" ; and Rhne-Poulenc S.A. "RP" ; into the new entity Aventis, S.A. "Aventis" ; . Pursuant to article 6 2 ; of the above referred Council Regulation , and in order to remove any anticompetitive effect which the proposed merger of Hoechst AG and Rhne-Poulenc S.A. together collectively referred to as the Parties ; may have on the J1F market in France, the Parties submit to the Commission the hereinafter commitment. 'HILQLWLRQV i ; "Hoechst" means Hoechst AG, its directors, officers, employees, agents and representatives, predecessors, successors, and assigns; the subsidiaries, divisions, groups and affiliates controlled by Hoechst, and the respective directors, officers, employees, agents, and representatives, successors, and assigns of each. ii ; "RP" means Rhne-Poulenc S.A., its directors, officers, employees, agents and representatives, predecessors, successors, and assigns; the subsidiaries, divisions, groups and affiliates controlled by RP, and the respective directors, officers, employees, agents, and representatives, successors, and assigns of each. iii ; "Aventis" means Aventis S.A., its directors, officers, employees, agents and representatives, predecessors, successors, and assigns: the subsidiaries, divisions, groups and affiliates controlled by Aventis, and the respective directors, officers, employees, agents, and representatives, successors, and assigns of each. iv ; "Commission" means the Commission of the European Communities. v ; "Josacine" means the corresponding pharmaceutical product that is the subject of the licence agreement dated February 7, 1978 by and between Yamanouchi International Limited now Yamanouchi Pharmaceuticals Co., Ltd ; and Bellon legal successor of Pharmuka Groupe Pechiney Ugine Kuhlmann, and part of the Rhne-Poulenc Group ; , all rights relating to the research, development, manufacture, existing product and marketing registration and sale of Josacine in France, including patent rights, know-how and the solutab technology for Josacine in France granted in the additional licence agreement dated July 13, 1998 by and between the same parties. vi ; "Yamanouchi" means Yamanouchi Pharmaceutical Co., Ltd, a Japanese corporation, and Yamanouchi Europe B.V. with its office and principal place of business located respectively at n 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, Japan, and Elisabethhof 19, 2353 EW Leiderdorp, The Netherlands, and includes its directors, officers, employees, agents and representatives, predecessors, successors, and assigns, licensees, the subsidiaries, divisions, groups and affiliates controlled by Yamanouchi, and the respective directors, officers, employees, agents, and representatives, successors, and assigns of each. Both direct and indirect costs are taken into account when conducting pharmacoeconomic studies. The cost of hospital staff nurses, pharmacists, etc ; is considered: a. Fixed direct costs b. Variable direct costs c. Indirect costs d. Fixed or variable direct costs, depending on full-time vs part-time employment status e. Fixed or variable costs, depending on the level of benefits the employee receives 2 ; In the meta-analysis of 31 studies on MRSA infections by Cosgrove and colleagues, MRSA infections were associated with: a. An approximate twofold increase in mortality for the main group, which was also seen in subgroup analysis that adjusted for comorbidities and severity of disease b. An approximate twofold increase in mortality for the main group, but no differences in the subgroup analysis that adjusted for comorbidities and severity of disease c. No effect on mortality in the main group analysis, but an approximate twofold increase in subgroup analysis for comorbidities or disease severity 3 ; In the cost analysis by Lodise and colleagues that compared MRSA and MSSA infections in a hospital setting, higher cost for MRSA infection was observed for the: a. Variable direct costs b. Fixed direct costs c. Indirect costs d. Variable and fixed direct costs, but not the indirect costs e. All 3 cost groups. 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